Neurological Puzzles After Radiotherapy: Mysterious Clues of Smart Syndrome, Two Case Reports.
Ahmet Baytok, Halil Ozer, Hakan Cebeci et al.
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Case in brief
This report discusses two patients who developed SMART syndrome, presenting with stroke-like symptoms and migraine-like headaches years after undergoing brain radiotherapy. MRI findings revealed transient cortical hyperintensities and contrast enhancement, aiding in the diagnosis. Awareness of this condition is crucial to avoid misdiagnosis as stroke or tumor recurrence, which could result in unnecessary interventions.
Diagnostic / clinical pearl
Clinicians should consider SMART syndrome in patients with neurological symptoms following brain radiotherapy, as MRI findings can help differentiate it from stroke or tumor recurrence.
Why it matters
Recognizing SMART syndrome can prevent misdiagnosis and unnecessary treatments, highlighting the importance of awareness in managing post-radiotherapy neurological complications.