Micropapillary Serous Borderline Tumor With Microinvasive Low-Grade Serous Carcinoma of the Tunica Vaginalis Harboring NRAS p.Q61R Mutation: Expanding the Molecular Spectrum of Paratesticular Müllerian-Type Tumors.
Baoling Xing, Xiaoying Zhang, Hui Zhu et al.
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Case in brief
A patient presented with a micropapillary serous borderline tumor of the tunica vaginalis, which also exhibited microinvasive low-grade serous carcinoma. Histopathological examination confirmed Müllerian differentiation. Genetic analysis revealed an NRAS p.Q61R mutation, suggesting a potential link to malignant progression. The case highlights the importance of molecular profiling in understanding tumor behavior and guiding management.
What made this case unusual
The identification of the NRAS p.Q61R mutation in this context is noteworthy, as NRAS mutations are rarely reported in serous tumors, indicating possible shared oncogenic pathways between male and female Müllerian-type neoplasms.
Diagnostic / clinical pearl
Clinicians should consider the possibility of NRAS mutations in paratesticular Müllerian-type tumors, as they may indicate a risk of malignant progression.
Why it matters
Understanding the molecular characteristics of these rare tumors can inform long-term surveillance strategies and potential therapeutic targets.