Relevance of tumour-infiltrating lymphocytes in oral mucosal melanoma: a systematic review.

Int J Oral Maxillofac SurgApr 22, 2026 (epub)
Clinical ResearchOncology (Medical)

C F J Bakhuis, E J de Ruiter, R de Bree et al.

✦ AI-curated · Sources linked

In 30 seconds

This systematic review evaluated the prognostic significance of tumour-infiltrating lymphocytes (TILs) in oral mucosal melanoma (OMM), analyzing data from two studies involving 102 patients. Approximately 25% of OMM patients exhibited TILs, with higher levels linked to improved overall survival in one study. The findings suggest TILs may serve as a prognostic marker in OMM.

Key findings

  • Approximately 25% of OMM patients had demonstrable TILs.
  • High TIL levels were associated with improved overall survival in one study.
  • Low TIL levels significantly correlated with an increased risk of distant metastasis.

Why it matters

Identifying reliable prognostic markers like TILs in OMM can enhance patient management and counselling, potentially leading to better treatment strategies and outcomes.

Source

PubMed · PMID 42025485

Published in Int J Oral Maxillofac Surg. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

ShareTelegramLinkedIn

AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

More in Oncology (Medical)

Clinical ResearchVascular SurgeryOpen access

Revascularization of Asymptomatic Carotid Artery Stenosis: Cognitive Results of the CREST-2 Randomized Trials.

This prespecified cognitive-outcomes analysis of the multicentre, randomised CREST-2 trials assessed patients aged 35 years or older with at least 70% asymptomatic carotid stenosis.

JAMAOct 27, 2026Read summary
Clinical ResearchObstetrics & GynecologyOpen access

Intrauterine Mepivacaine Instillation vs Placebo for Pain During IUD Placement: A Randomized Clinical Trial.

This multicentre, double-blind, randomised, placebo-controlled trial tested intrauterine mepivacaine before IUD placement in nulliparous individuals aged 18 to 31 years at 11 Swedish clinics.

JAMAOct 27, 2026Read summary
Clinical ResearchOncology (Medical)

Zamtocabtagene autoleucel, a tandem CD20-CD19-directed CAR T-cell therapy, for second line treatment of large B-cell lymphoma in patients ineligible for transplantation (DALY 2-EU): primary analysis of an open-label, multicentre, randomised phase 2 study.

DALY 2-EU was an open-label, multicentre, randomised phase 2 trial comparing tandem CD20-CD19-directed zamtocabtagene autoleucel (zamto-cel) with R-GemOx in adults with second-line relapsed or refractory large B-cell…

Lancet OncolOct 27, 2026Read summary

Want this personalized?

Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.

  • Your specialties
  • Your filters and thresholds
  • Clinical Research + Case Reports, tuned separately
  • Automatic weekly delivery
  • Audio and text
Create my personalized digestSee plans

Prefer listening? Personalized audio digests are available with Pro.

Stay updated for free

Get the 3 most interesting publications in one specialty each week.

Weekly email. Unsubscribe anytime.