Digital interoceptive-enhanced exercise for young adults with depression: A randomized controlled trial.

J Affect DisordApr 21, 2026 (epub)
Clinical ResearchPsychiatry

Yisheng Aku, Yanpeng Jin, Diyang Qu et al.

✦ AI-curated · Sources linked

In 30 seconds

This randomized controlled trial evaluated a digital intervention combining structured physical activity with interoceptive training in 46 young adults with mild to moderate depressive symptoms. The intervention led to a significant reduction in depressive symptoms at post-test, with an adjusted mean difference of 3.47. However, these improvements were not maintained at follow-up.

Key findings

  • The intervention group showed a significant reduction in depressive symptoms at post-test (adjusted mean difference = 3.47).
  • Secondary outcomes, including well-being and interoceptive ability, also improved at post-test.
  • Improvements in depressive symptoms were not sustained at one-month or three-month follow-up.

Why it matters

This study highlights the potential of integrating interoceptive training with physical activity to provide short-term relief from depressive symptoms in young adults, addressing a critical gap in scalable treatment options.

Source

PubMed · PMID 42025636

Published in J Affect Disord. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

ShareTelegramLinkedIn

AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

More in Psychiatry

Clinical ResearchOncology (Medical)

Zamtocabtagene autoleucel, a tandem CD20-CD19-directed CAR T-cell therapy, for second line treatment of large B-cell lymphoma in patients ineligible for transplantation (DALY 2-EU): primary analysis of an open-label, multicentre, randomised phase 2 study.

DALY 2-EU was an open-label, multicentre, randomised phase 2 trial comparing tandem CD20-CD19-directed zamtocabtagene autoleucel (zamto-cel) with R-GemOx in adults with second-line relapsed or refractory large B-cell…

Lancet OncolOct 27, 2026Read summary
Clinical ResearchOncology (Medical)

Neoadjuvant short-course radiotherapy followed by camrelizumab and chemotherapy versus standard of care for locally advanced rectal cancer (UNION): a prespecified interim analysis of a multicentre, open-label, randomised, phase 3 trial.

UNION was a multicentre, open-label, randomised phase 3 trial at nine hospitals in China comparing neoadjuvant short-course radiotherapy followed by camrelizumab plus CAPOX with long-course chemoradiotherapy followed by…

Lancet OncolOct 25, 2026Read summary
Clinical ResearchHematology

Efficacy and safety of mitapivat in patients with sickle cell disease (RISE UP): a phase 3, double-blind, global, randomised, placebo-controlled trial.

RISE UP was a phase 3, double-blind, global, randomised, placebo-controlled trial conducted at 69 sites in 15 countries. It evaluated twice-daily mitapivat in patients older than 16 years with sickle cell disease…

LancetOct 24, 2026Read summary

Want this personalized?

Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.

  • Your specialties
  • Your filters and thresholds
  • Clinical Research + Case Reports, tuned separately
  • Automatic weekly delivery
  • Audio and text
Create my personalized digestSee plans

Prefer listening? Personalized audio digests are available with Pro.

Stay updated for free

Get the 3 most interesting publications in one specialty each week.

Weekly email. Unsubscribe anytime.