Clinical Significance of Renal Tissue in Neonatal Sacrococcygeal Teratoma: A Case Report With Review of Literature.

Pediatr Dev PatholApr 24, 2026 (epub)
Case ReportPathology (Anatomic & Clinical)PediatricsOncology (Medical)General SurgeryOpen access

Alessio Conte, Silvia Rebella, Gabriele Gaggero et al.

✦ AI-curated · Sources linked

Case in brief

A neonate with a sacrococcygeal teratoma (SCT) had renal differentiation within the tumor, including a minor component interpreted as nephroblastoma. The authors reviewed newborn cases with renal tissue identified in SCTs: among 19 patients, renal tissue was classified as immature or ectopic nephrogenic tissue in 15 and as Wilms tumor in 4. All underwent surgical resection; some also received chemotherapy or radiotherapy. At a median follow-up of 29.5 months (range, 4-154), there were no cancer-related deaths.

What made this case unusual

The diagnostic challenge was distinguishing immature nephrogenic tissue from true nephroblastoma within an SCT; accepted criteria for classifying this renal differentiation are lacking.

Diagnostic / clinical pearl

Renal tissue in an SCT should be assessed carefully: immature nephrogenic tissue and Wilms tumor may be difficult to distinguish, so interpretation and management warrant multidisciplinary consideration.

Source

PubMed · PMID 42029172Free full text on PubMed Central

Published in Pediatr Dev Pathol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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