Efficacy of adjunctive intermittent theta-burst stimulation on depressive and insomnia symptoms in elderly patients with depression and comorbid insomnia: A randomized, sham-controlled trial.
J Affect DisordApr 22, 2026 (epub)
Jiaojiao Zhou, Kemeng Zhu, Yida Wang et al.
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In 30 seconds
This randomized, sham-controlled trial investigated the effects of intermittent theta-burst stimulation (iTBS) on depressive and insomnia symptoms in 36 elderly patients with late-life depression and comorbid insomnia. Active iTBS significantly improved symptoms compared to sham stimulation (p < 0.05), suggesting its potential as an adjunctive treatment in this population.
Key findings
- Active iTBS significantly improved depressive symptoms compared to sham stimulation.
- Active iTBS significantly improved insomnia symptoms compared to sham stimulation.
- Reductions in ALFF in limbic-temporal regions correlated with sleep improvement.
Why it matters
The findings indicate that iTBS may offer a new therapeutic option for elderly patients suffering from both depression and insomnia, conditions that often coexist and complicate treatment.
What to keep in mind
Larger multi-center trials with prolonged follow-up are needed to confirm findings and elucidate mechanisms.