Predictors of fluoroquinolone-resistant bacterial colonization prior to prostate biopsy: a secondary analysis of two randomized trials.
Prostate Cancer Prostatic DisApr 27, 2026 (epub)
Daniel Barbakoff, Gal Wald, Mary Oakley Strasser et al.
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In 30 seconds
This study analyzed predictors of fluoroquinolone-resistant (FQR) bacterial colonization in men undergoing prostate biopsy, using data from two multicenter randomized trials. Among 925 patients, FQR colonization was found in 16% (145 patients). Increased odds of FQR colonization were noted at one site (OR 3.68), and FQR bacteria were linked to a higher risk of post-biopsy infections (3.9% vs. 0.8%).
Key findings
- FQR bacterial colonization was found in 16% of patients (145 out of 925).
- One site had significantly increased odds of FQR colonization (OR 3.68, p < 0.001).
- Post-biopsy infection risk was higher with FQR bacteria (3.9% vs. 0.8%, p = 0.017).
- Asian men showed an insignificantly increased odds of FQR colonization (OR 1.94, p = 0.070).
Why it matters
Understanding predictors of FQR colonization is crucial for clinicians to mitigate the risk of infectious complications following prostate biopsy. Identifying high-risk populations can inform targeted prophylactic strategies.