Bacterial Lysates Add-On Therapy to Reduce Postoperative Recurrence in Nasal Polyps.
LaryngoscopeApr 27, 2026 (epub)
Clinical ResearchOtolaryngology (ENT)
Huiyi Deng, Huijun Qiu, Tian Yuan et al.
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In 30 seconds
This randomized controlled trial evaluated the effect of OM-85 on postoperative polyp recurrence in 100 patients with nasal polyps. The study found that the polyp recurrence rate was significantly lower in the OM-85 group (8.82%) compared to the control group (27.91%, p = 0.036).
Key findings
- Polyp recurrence rate was 8.82% in the OM-85 group versus 27.91% in the control group (p = 0.036).
- Significant improvements in nasal obstruction and olfactory dysfunction were observed at 6 and 12 months (p < 0.05).
- Lund-Kennedy and SNOT-22 scores improved significantly in the OM-85 group (p < 0.05).
- Elevated white blood cell counts and lymphocyte percentages were noted from 6 months onward (p < 0.05).
Why it matters
The findings suggest that OM-85 may be an effective adjunct therapy to reduce polyp recurrence and improve patient-reported outcomes after surgery for nasal polyps, highlighting its potential role in enhancing postoperative care.