Intralesional secukinumab for localized, recalcitrant hidradenitis suppurativa: a case series of rapid symptom relief.

J Dermatolog TreatApr 27, 2026 (epub)
Case ReportDermatology

Junyou Zheng, Dong Luo, Ke Zhang et al.

✦ AI-curated · Sources linked

Case in brief

This case series evaluated the use of intralesional secukinumab in five patients with localized, recalcitrant hidradenitis suppurativa (HS) who had not responded to conventional therapies. Following treatment, all lesions exhibited significant reduction in inflammation and size, with improvements reflected in patient-reported VAS and DLQI scores. No severe adverse events were reported.

Diagnostic / clinical pearl

Intralesional secukinumab may provide rapid symptom relief for localized hidradenitis suppurativa lesions that are resistant to standard treatments.

Why it matters

This approach offers a potential new adjunctive treatment strategy for managing difficult HS cases, addressing a significant unmet clinical need.

Source

PubMed · PMID 42041266

Published in J Dermatolog Treat. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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