Optical coherence tomography measurements in retinopathy of prematurity: A systematic review and meta-analysis.
Sayena Jabbehdari, Sepehr Fekrazad, Anthony Oganov et al.
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In 30 seconds
This systematic review and meta-analysis evaluated retinal and choroidal structural changes in individuals with a history of retinopathy of prematurity (ROP) compared to healthy controls. The analysis included 11 studies with 1,019 participants. Results showed that ROP eyes had significantly thinner macular ganglion cell-inner plexiform layer thickness (SMD -1.07; p = 0.002) and increased foveal retinal thickness (SMD 1.41; p < 0.0001).
Key findings
- ROP eyes had thinner macular ganglion cell-inner plexiform layer thickness (SMD -1.07; p = 0.002).
- Foveal retinal thickness was significantly increased in ROP eyes (SMD 1.41; p < 0.0001).
- No significant difference was found in subfoveal choroidal thickness.
- Younger age at imaging was associated with greater foveal thickening (p = 0.002).
Why it matters
Understanding the structural alterations in the retina and choroid of individuals with a history of ROP can inform clinicians about potential long-term visual outcomes and guide monitoring strategies.
What to keep in mind
Substantial heterogeneity was present across most outcomes, limiting the generalizability of the findings.