Clinical effects of pharmacological and electronic cigarette interventions for smoking cessation in pregnancy: a systematic review and network meta-analysis.
Phiyanuch Thimkorn, Chimbun Booncharoen, Panitnan Chaipitak et al.
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In 30 seconds
This systematic review and network meta-analysis evaluated the effectiveness of pharmacological and electronic cigarette interventions for smoking cessation in pregnant women. Analyzing 11 randomized controlled trials with 4,065 participants, the study found that the combination of nicotine patch and gum significantly improved point prevalence abstinence (RR 3.22) compared to usual care, while E-cigarettes also showed effectiveness (RR 1.81).
Key findings
- Nicotine patch and gum combination improved point prevalence abstinence (RR 3.22; 95% CI: 1.40, 7.39).
- E-cigarette use significantly increased point prevalence abstinence (RR 1.81; 95% CI: 1.11, 2.93).
- Nicotine gum was associated with higher birthweight (MD 337.00; 95% CI: 103.18, 570.82).
- Nicotine gum reduced the risk of preterm birth (RR 0.39; 95% CI: 0.17, 0.91).
Why it matters
Smoking during pregnancy poses significant risks to both maternal and fetal health. Effective cessation strategies are crucial for improving outcomes, making this analysis of pharmacological and electronic cigarette interventions particularly relevant for clinicians working with pregnant patients.
What to keep in mind
The findings are based on a limited number of studies, and the quality of included trials varied, with some showing high risk of bias.