Multicentric Reticulohistiocytosis Induced Alopecia: A Clinical Case Report.
Hayley Zimbric, Gabrielle Brokamp, Catherine G Chung et al.
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Case in brief
A 52-year-old female presented with red-brown papules, finger swelling, and muscle pain. Biopsy confirmed multicentric reticulohistiocytosis (MRH) with characteristic histiocyte proliferation. Following treatment with prednisone, methotrexate, folic acid, and adalimumab, the patient developed progressive hair loss localized to the frontal scalp. A scalp biopsy revealed follicular involvement by histiocytes, leading to a diagnosis of alopecia secondary to MRH.
What made this case unusual
This case highlights the association of alopecia with multicentric reticulohistiocytosis, a rare manifestation not previously reported in the literature.
Diagnostic / clinical pearl
Clinicians should consider the possibility of alopecia in patients with multicentric reticulohistiocytosis, especially when there is follicular involvement.
Why it matters
Recognizing this association can aid in the comprehensive management of patients with MRH and prevent misdiagnosis of alopecia.