Hydrogen peroxide 40% versus trichloroacetic acid 70% in the treatment of seborrheic keratosis.
Hanaa Samy Mohamed Othman, Osama A Hashem, Osama Elshabory et al.
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In 30 seconds
This randomized controlled trial compared the efficacy and safety of hydrogen peroxide 40% (H2O2) and trichloroacetic acid 70% (TCA) in treating seborrheic keratosis in 64 patients. TCA demonstrated significantly greater efficacy, achieving complete lesion clearance in 43.8% of cases compared to 0% for H2O2 (p < 0.001).
Key findings
- Complete lesion clearance was achieved in 43.8% of TCA-treated patients versus 0% in the H2O2 group (p < 0.001).
- Dermoscopic clearance occurred in 56.3% of TCA patients compared to 6.3% for H2O2 (p < 0.001).
- Patient satisfaction was significantly higher with TCA treatment (p = 0.001).
- Mild scarring was observed in 25% of TCA-treated patients, while H2O2 showed no scarring.
Why it matters
Understanding the comparative effectiveness and safety of treatments for seborrheic keratosis is crucial for clinicians to make informed decisions about patient care, particularly in balancing efficacy with potential adverse effects.
What to keep in mind
The study's limitations include a single-center design, small sample size, short follow-up, and lack of prospective trial registration.