Late-onset diagnosis of gestational diabetes after normal mid-pregnancy screening in women with large for gestational age or polyhydramnios: a systematic review and meta-analysis.
Omri Dominsky, Roza Berkovitz-Shperling, Michal Rosenberg-Fridman et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the detection rate of late-onset gestational diabetes mellitus (GDM) in women with normal mid-pregnancy glucose screening who underwent repeat testing due to suspected large-for-gestational-age fetuses or polyhydramnios. Among 2166 women, the pooled detection rate was 15.0%. The study highlights significant associations between late-onset GDM and adverse perinatal outcomes.
Key findings
- The pooled detection rate of late-onset GDM was 15.0% (95% CI, 9.9%-21.0%).
- Detection rates were 20.8% for suspected large for gestational age vs 4.8% for isolated polyhydramnios.
- Late-onset GDM was associated with a 1.82 odds ratio for neonatal hypoglycemia.
- The odds ratio for overall cesarean delivery was 2.00.
Why it matters
Understanding the detection rates and associated risks of late-onset gestational diabetes is crucial for clinicians to make informed decisions regarding third-trimester glucose testing and management of pregnancies at risk for complications.