Efficacy of polyphenolic compounds for hair regeneration: a systematic review and meta-analysis of randomized controlled trials.
Chaimae El Ammari, Ana María García-Muñoz, Rubén Zapata-Pérez et al.
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In 30 seconds
This systematic review and meta-analysis assessed the efficacy of polyphenolic compounds for hair regeneration in adults with non-scarring alopecia, analyzing 32 randomized controlled trials with 2,183 participants. The findings indicated significant improvements in hair density (SMD 0.90) and total area hair count (SMD 1.03) compared to controls, although no significant differences were found when compared directly to minoxidil.
Key findings
- Polyphenolic interventions significantly improved hair density with a standardized mean difference (SMD) of 0.90.
- Total area hair count increased significantly with polyphenolic compounds, showing an SMD of 1.03.
- No significant differences were observed in overall hair count outcomes when compared directly to minoxidil.
- The analysis included 32 randomized controlled trials with a total of 2,183 participants.
Why it matters
The study highlights the potential of polyphenolic compounds as an adjunctive treatment for non-scarring alopecia, offering an alternative for patients who may not respond well to conventional therapies like minoxidil or finasteride.