Efficacy and safety of menopausal hormone therapy for depressive symptoms in perimenopausal women: A systematic review and meta-analysis.
J Affect DisordApr 28, 2026 (epub)
Yixuan Li, Yilin Sun, Yu Bi et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the effects of hormone replacement therapy (HRT) on depressive symptoms in perimenopausal women. Analyzing twelve randomized controlled trials, the study found that HRT was associated with a small reduction in depressive symptom severity (SMD = -0.23, 95% CI -0.43 to -0.03) compared to placebo. The evidence regarding different HRT regimens was inconclusive.
Key findings
- HRT was associated with a small reduction in depressive symptom severity (SMD = -0.23, 95% CI -0.43 to -0.03).
- Subgroup analyses indicated larger effects for tibolone or selective tissue estrogenic activity regulator-based regimens, though not statistically significant.
- Adverse events reported were generally mild to moderate.
Why it matters
Understanding the impact of HRT on depressive symptoms in perimenopausal women is crucial for clinicians managing mental health during this transitional phase. This evidence may inform treatment decisions regarding HRT use.