Omics in hereditary optic neuropathies: A systematic review of clinical studies with an integrated point of view.

In 30 seconds

This systematic review examined the application of omics strategies in understanding hereditary optic neuropathies, focusing on 22 clinical studies. The review highlighted common pathophysiological mechanisms such as energetic impairment and oxidative stress, suggesting potential new biomarkers and therapeutic targets for conditions like Leber hereditary optic neuropathy and OPA1-related dominant optic atrophy.

Key findings

• 22 articles were included from an initial 1244 references screened.
• Common pathophysiological mechanisms identified include energetic impairment and oxidative stress.
• The review suggests potential new biomarkers and therapeutic targets for hereditary optic neuropathies.

Why it matters

Understanding the molecular alterations in hereditary optic neuropathies can enhance diagnostic accuracy and inform the development of targeted therapies, ultimately improving patient outcomes in these complex conditions.