Neonatal and obstetric outcomes following periconceptional exposure to glucagon-like peptide-1 receptor agonists: a systematic review and meta-analysis.
Jolie Hakim, Diya Rajesh, Javier Ananda Tello
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From the abstract
To evaluate the association between periconceptional exposure to glucagon-like peptide-1 receptor agonists and fetal, pregnancy-related, obstetric, and delivery outcomes.
Reported results
Twenty-two studies, comprising 49,395 human pregnancies with periconceptional glucagon-like peptide-1 receptor agonist exposure, were included. Meta-analysis of 10 cohort and observational studies showed no statistically significant association between exposure and major congenital malformations, cardiac malformations, gestational age and weight, preterm delivery, live birth, spontaneous pregnancy loss, hypertensive…
Authors' conclusions
Current human evidence does not demonstrate a consistent association between periconceptional glucagon-like peptide-1 receptor agonist exposure and major adverse fetal, pregnancy, obstetric, or labor outcomes. The observed risk for renal malformations should be interpreted with caution as it likely reflects residual confounding by maternal disease severity.