Effect of Preoperative Systemic Steroids on Tissue Eosinophils in CRSwNP: Meta-Analysis.
Wirach Chitsuthipakorn, Vorachai Pooldum, Minh P Hoang et al.
✦ AI-curated · Sources linked
In 30 seconds
This meta-analysis evaluated the impact of preoperative systemic corticosteroids on tissue eosinophil count (TEC) in adults with chronic rhinosinusitis with nasal polyps (CRSwNP). Seventeen studies involving 930 participants were analyzed, revealing that systemic steroids significantly reduced TEC/HPF by a mean difference of -36.57 cells. The findings suggest that corticosteroids may affect histologic assessments during surgery.
Key findings
- Systemic steroids reduced TEC/HPF by a mean difference of -36.57 cells.
- The percentage of eosinophils among inflammatory cells (%TEC) decreased by a mean difference of -18.14.
- Low-dose steroids (4.2-18.6 mg/day) showed a non-significant reduction in TEC.
- Adverse events were not significantly different between steroid and control groups (5.60% vs. 1.12%).
Why it matters
Understanding the effects of preoperative systemic corticosteroids on eosinophil counts is crucial for accurate histological evaluation in CRSwNP patients. This knowledge can guide clinicians in making informed decisions regarding steroid use before surgery.