Remarkable efficacy of ivonescimab-based second-line therapy in advanced lung adenocarcinoma resistant to chemoimmunotherapy: a case report.

Anticancer DrugsSep 9, 2026 (epub)
Case ReportOncology (Medical)

Xuan Wang, Kunning Yang, Ping Yin

✦ AI-curated · Sources linked

Case in brief

A 41-year-old male with stage IVA lung adenocarcinoma, initially treated with camrelizumab, pemetrexed, and carboplatin, experienced disease progression after achieving a partial response. Upon switching to second-line therapy with ivonescimab and docetaxel, the patient attained a significant clinical and radiographic response, sustaining a partial response over 12 treatment cycles, with progression-free survival exceeding 12 months.

Diagnostic / clinical pearl

This case illustrates the potential efficacy of ivonescimab-based therapy in advanced lung adenocarcinoma patients who have progressed on prior immunotherapy, even with low PD-L1 expression.

Source

PubMed · PMID 42068723

Published in Anticancer Drugs. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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