Response of undifferentiated and dedifferentiated endometrial cancer to pembrolizumab: a case report.

Anticancer DrugsApr 21, 2026 (epub)
Case ReportOncology (Medical)

Peter G Rose, Johanna Kelley, Aaron Petty et al.

✦ AI-curated · Sources linked

Case in brief

This case report discusses the use of pembrolizumab in a cohort of patients with undifferentiated and dedifferentiated endometrial cancer. Among 11 patients treated, 10 were found to be mismatch repair-deficient. The treatment resulted in three partial responses and two complete responses, both occurring in patients who received pembrolizumab alongside chemotherapy. Adverse effects included colitis and hepatitis.

Diagnostic / clinical pearl

Clinicians should consider the high prevalence of mismatch repair deficiency in undifferentiated and dedifferentiated endometrial cancers when evaluating treatment options, particularly the potential benefits of combining immunotherapy with chemotherapy.

Why it matters

This case highlights the importance of recognizing the histologic type of endometrial cancer, as it may influence treatment strategies and outcomes, particularly in advanced stages.

Source

PubMed · PMID 42068992

Published in Anticancer Drugs. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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