Rosai-Dorfman Disease of the Breast: A Case Series and Review of the Literature.
Alba Rebecca Hernandez Guzman, Romina Malerba, Yuan Rong et al.
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Case in brief
Three women aged 22 to 71 years were diagnosed with Rosai-Dorfman disease of the breast, presenting with palpable masses or an incidental finding on imaging. Imaging studies indicated suspicious masses categorized as BI-RADS 4-5. Histopathology revealed characteristic lymphoplasmacytic infiltrates and positive immunohistochemical markers. Two patients underwent excision, while one was managed conservatively, with all remaining disease-free at follow-up.
Diagnostic / clinical pearl
Breast Rosai-Dorfman disease can mimic malignancy on imaging, making histopathologic evaluation crucial for accurate diagnosis.
Why it matters
Awareness of this rare presentation is important to avoid misdiagnosis and unnecessary aggressive treatment.