Comparative effects of non-pharmacological interventions on anxiety, depression and quality of life in individuals with substance use disorders: A systematic review and network meta-analysis.
Haoran Luo, Yiman Xiong, Xianming Ding et al.
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In 30 seconds
This systematic review and network meta-analysis evaluated the efficacy of non-pharmacological interventions for anxiety, depression, and quality of life in individuals with substance use disorders (SUDs). Analyzing 117 RCTs with 11,177 participants, the study found that neuromodulation was the top-ranked intervention for anxiety and quality of life, while mind-body therapy ranked highest for depression. Short-term improvements in anxiety and depression were noted, but quality of life effects were uncertain.
Key findings
- Neuromodulation showed significant reductions in anxiety symptoms compared to control.
- Mind-body therapy ranked highest for reducing depression symptoms among interventions.
- Quality of life improvements were uncertain, with imprecise estimates at the earliest post-intervention time point.
- Subgroup analyses indicated varying effects based on country development level and intervention duration.
Why it matters
Understanding the comparative effectiveness of non-pharmacological interventions can guide clinicians in selecting appropriate treatments for individuals with substance use disorders, potentially improving mental health outcomes and quality of life.