Adenomatoid Tumor of the Uterus With Marked Nuclear Atypia: A Case Report Including Next-Generation Sequencing Analysis and Review of the Literature.
Jiří Lenz, Květoslava Michalová, Nikola Ptáková et al.
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Case in brief
A 51-year-old woman presented with multiple uterine nodules during a total abdominal hysterectomy for leiomyomas. Histological examination revealed an adenomatoid tumor with marked nuclear atypia, characterized by hyperplastic leiomyocytes and bizarre pleomorphic cells. Despite the atypical features, the tumor exhibited no aggressive behavior or malignant transformation, and the patient's condition was managed successfully.
What made this case unusual
The presence of severe nuclear atypia and pleomorphism in the adenomatoid tumor posed significant diagnostic challenges, potentially leading to misdiagnosis.
Diagnostic / clinical pearl
Clinicians should be aware that adenomatoid tumors can exhibit marked nuclear atypia, which may complicate diagnosis but does not necessarily indicate malignancy.
Why it matters
Understanding the atypical histopathological features of adenomatoid tumors is crucial for accurate diagnosis and management, particularly in patients with a history of hormone therapy.