Zinc-Induced Hematologic Toxicities: A Systematic Review of Descriptive Studies.
Biol Trace Elem ResMay 6, 2026 (epub)
Archita Dutta, Vaibhav Chaudhary, Sweta Kumari et al.
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In 30 seconds
This systematic review analyzed 34 studies detailing zinc-induced hematologic toxicities in humans, highlighting that excessive zinc exposure can lead to anemia, neutropenia, and leukopenia. The review found that nearly all cases presented with anemia, often alongside neutropenia and leukopenia, and that discontinuation of zinc with copper supplementation led to recovery in most patients.
Key findings
- Anemia was present in nearly all cases, often with neutropenia and leukopenia.
- Zinc exposure commonly resulted from oral supplements, denture adhesives, and coin ingestion.
- Discontinuation of zinc exposure with copper supplementation led to recovery in the majority of cases.
- Bone marrow examinations frequently revealed vacuolated hematopoietic precursors and ring sideroblasts.
Why it matters
Clinicians should be aware of zinc-induced hematologic toxicities, as they can present with unexplained anemia and cytopenias. Recognizing excessive zinc exposure can facilitate timely diagnosis and treatment, potentially preventing long-term complications.