The role of intraoperative tranexamic acid in transurethral resection of the prostate: a systematic review and meta-analysis of randomised-controlled trials.
Int Urol NephrolMay 7, 2026 (epub)
Cian M Hehir, Gavin G Calpin, Gavin P Dowling et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the safety and efficacy of intraoperative tranexamic acid (TXA) during transurethral resection of the prostate (TURP) in 661 patients with benign prostatic hyperplasia. The study found that TXA significantly reduced intraoperative bleeding (MD -40.23 mL) and operative time (MD -9.77 min), while also decreasing the need for blood transfusions (0.99% TXA vs. 7.69% Control).
Key findings
- TXA reduced intraoperative bleeding by 40.23 mL compared to control (p = 0.003).
- Postoperative hemoglobin drop was significantly lower in the TXA group (MD -0.55 g/dL, p < 0.00001).
- Operative time was significantly shorter with TXA, averaging 9.77 minutes less (p = 0.008).
- Blood transfusion rates were significantly lower in the TXA group (0.99% vs. 7.69%, OR 0.16, p = 0.04).
Why it matters
The findings suggest that intraoperative TXA can enhance surgical outcomes in TURP by minimizing blood loss and reducing the need for transfusions, which may improve patient recovery and resource utilization.