On the optimal sodium correction rate in hyponatraemia and clinical outcome: a meta-analysis.
Emerg Med JSep 18, 2026 (epub)
Ludwig Matrisch, Yannick Rau, Lars Graßhoff et al.
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In 30 seconds
This meta-analysis examined the impact of sodium correction rates on mortality in patients with hyponatraemia, analyzing 11 studies with 27,672 cases. It found that rapid correction (8, 10, and 12 mmol/L/24 hours) was associated with significantly lower mortality rates (OR: 0.398, p<0.001 for 8 mmol/L/day).
Key findings
- Mortality was significantly lower in the rapid correction group compared to the slow correction group for all thresholds.
- For the 8 mmol/L/day threshold, the odds ratio for mortality was 0.398 (p<0.001).
- The overall incidence of osmotic demyelination syndrome was low at 0.085%, but higher in the rapid correction group (OR: 3.959, p=0.002).
Why it matters
Understanding the optimal sodium correction rate is crucial for clinicians managing hyponatraemia, as it can significantly influence patient outcomes and mortality rates in emergency settings.