Lens-Induced Uveitis: A Systematic Review of Pathophysiology, Diagnosis, and Treatment.
Semin OphthalmolMay 8, 2026 (epub)
Clinical ResearchOphthalmology
María Elisa Rodríguez-Malagón, Andrea Salazar-Vitale, Natalia Mayela Cantón-Muñiz et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review examined lens-induced uveitis, an immune-mediated reaction to lens proteins, across 29 studies involving 252 eyes. The review found that 82.54% of cases had a disrupted lens capsule, and 64.69% of eyes had a final visual acuity of light perception or worse. Surgical removal of lens material was the main treatment, with earlier intervention linked to improved outcomes.
Key findings
- 82.54% of cases involved a disrupted lens capsule, highlighting the role of crystallin exposure.
- 64.69% of eyes had a final visual acuity of light perception or worse.
- Surgical removal of lens material was the predominant definitive treatment.
- Earlier intervention in recent reports was associated with better visual outcomes.
Why it matters
Understanding lens-induced uveitis is crucial for clinicians as it can lead to significant vision loss if not diagnosed and treated promptly. Awareness of its clinical features may facilitate earlier intervention.