Carbetocin vs oxytocin for prevention of postpartum hemorrhage in women with obesity undergoing cesarean delivery: A systematic review and meta-analysis.
Gabriela Francis, Kellen Crizel da Rocha, Bruna Benigna Sales Armstrong et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the effectiveness of carbetocin versus oxytocin in preventing postpartum hemorrhage in obese women undergoing cesarean delivery. Analyzing three randomized controlled trials with 269 participants, carbetocin was found to significantly reduce blood loss (MD -230.11 ml) and the incidence of postpartum hemorrhage (RR 0.19) compared to oxytocin.
Key findings
- Carbetocin reduced mean blood loss by 230.11 ml compared to oxytocin (p = 0.0014).
- Carbetocin resulted in significantly fewer blood transfusions (RR 0.14; p = 0.011).
- Carbetocin significantly reduced the incidence of postpartum hemorrhage (RR 0.19; p = 0.006).
Why it matters
The findings suggest that carbetocin may be more effective than oxytocin in preventing postpartum hemorrhage in obese women undergoing cesarean delivery, a population at higher risk for this complication. Understanding these differences can inform clinical decision-making in obstetric care.