A Systematic Review and Study-Level Meta-Analysis Investigating the Association Between Pre-endovascular Intervention C-Reactive Protein Levels and Femoropopliteal Artery Restenosis.
Ann Vasc SurgMay 6, 2026 (epub)
Clinical ResearchVascular Surgery
Hermann Pasha, Krishi Jain, Daniel O'Callaghan et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the relationship between pre-endovascular intervention C-reactive protein (CRP) levels and femoropopliteal artery restenosis in 2,097 patients. The analysis revealed a significant association, with a standardized mean difference of 0.44 (95% CI, 0.09-0.78, P = 0.01), indicating that higher CRP levels correlate with increased restenosis risk.
Key findings
- Pooled analysis showed a significant association between higher pre-intervention CRP levels and restenosis.
- Standardized mean difference was 0.44 with a 95% confidence interval of 0.09-0.78.
- The study included 14 studies with 2,097 patients, comprising 562 restenosis cases.
- No evidence of publication bias was found in the analysis.
Why it matters
Understanding the association between CRP levels and restenosis can help clinicians identify patients at higher risk for adverse outcomes following endovascular interventions, potentially guiding preoperative assessments and postoperative monitoring.