Effect of dexmedetomidine on cerebral homeostasis in patients undergoing craniotomy for brain tumour excision: A randomized double-blind trial.
Br J Clin PharmacolMay 8, 2026 (epub)
Anastasia Nikopoulou, Vasileios Grosomanidis, Aikaterina Poulopoulou et al.
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In 30 seconds
This randomized double-blind trial evaluated the effects of dexmedetomidine (DEX) on cerebral homeostasis in 56 patients undergoing craniotomy for brain tumor excision. DEX significantly reduced propofol consumption and improved cerebral oxygenation indices for 15 minutes post-infusion. Additionally, postoperative levels of biomarkers for cerebral injury and neuroinflammation were significantly lower in the DEX group (p < 0.01).
Key findings
- Propofol consumption was significantly reduced in the DEX group (p < 0.001).
- Cerebral oxygenation indices were favorably affected by DEX infusion (p < 0.05).
- Postoperative levels of S100B, NSE, TNF-α, IL-6, and cortisol were significantly lower in the DEX group (p < 0.01).
Why it matters
Understanding the effects of dexmedetomidine on cerebral oxygenation and inflammatory markers can inform anesthetic management during brain surgeries, potentially improving patient outcomes.