Effect of Smoking in Oropharyngeal Cancer Treated With TORS: Systematic Review and Meta-Analysis.
Jane Y Tong, Neha Amin, Cailin Cruess et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the impact of smoking on oncologic outcomes in 2079 patients with HPV-associated oropharyngeal squamous cell cancer (OPSCC) treated with transoral robotic surgery (TORS). The analysis found a hazard ratio of 2.7 for overall survival in smokers compared to non-smokers, indicating worse outcomes for smokers, although no significant differences were observed in recurrence-free or disease-specific survival.
Key findings
- Smokers had a hazard ratio of 2.7 for overall survival compared to non-smokers.
- No significant difference in recurrence-free survival between smokers and non-smokers was found.
- Disease-specific survival showed a hazard ratio of 1.4, but was not statistically significant.
- The study included 2079 patients across 12 studies with a median follow-up of 33.7 months.
Why it matters
Understanding the prognostic impact of smoking on OPSCC outcomes is crucial for risk stratification and patient counseling. This study highlights the need for further investigation into how smoking history influences survival in this patient population.