Plasmablastic Lymphoma Presenting With Multiple Cutaneous Nodules Mimicking Primary Cutaneous Marginal Zone Lymphoma.
Bo-Jung Chen, Feng-Jie Lai, Yin-Hsun Feng et al.
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Case in brief
A 73-year-old immunocompetent female presented with multiple cutaneous nodules and cervical lymphadenopathy. Biopsies of the nasopharynx and skin revealed EBV-associated plasmablastic lymphoma, which can mimic primary cutaneous marginal zone lymphoma. Despite treatment with multiagent chemotherapy, the patient's condition progressed, leading to her death within nine months.
Diagnostic / clinical pearl
Clinicians should consider plasmablastic lymphoma in patients with cutaneous lesions, even in the absence of immunocompromise, as it can mimic other lymphoproliferative disorders.
Why it matters
This case highlights the importance of thorough diagnostic evaluation to differentiate between similar lymphomas, particularly in immunocompetent patients.