Vascular and Wound-Healing Implications of Single-Stage Versus Multistage Repair of Anorectal Malformations: A Systematic Review and Meta-Analysis.
J Invest SurgMay 11, 2026 (epub)
Yu Du, Yiwei Wang, Wenjing Wang et al.
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In 30 seconds
This systematic review and meta-analysis evaluated wound-related complications and long-term functional outcomes of single-stage versus multistage repair of anorectal malformations (ARMs) in neonates and infants. The analysis included 1,972 patients from 19 studies. Single-stage repair was associated with a significantly higher risk of wound dehiscence (OR 3.31; 95% CI 1.90-5.79; p < 0.0001).
Key findings
- Single-stage repair had a higher risk of wound dehiscence (OR 3.31; 95% CI 1.90-5.79; p < 0.0001).
- No significant differences were found in surgical site infection rates between the two approaches.
- Long-term functional outcomes were comparable between single-stage and multistage repairs.
- Moderate to high heterogeneity was noted for selected outcomes.
Why it matters
Understanding the implications of surgical approaches for ARMs is crucial for optimizing patient outcomes. The increased risk of wound dehiscence with single-stage repair highlights the need for careful surgical technique and postoperative management.