The effects of neuromodulation through brainwave entrainment on pain in women with fibromyalgia: a randomized controlled clinical trial with follow-up.
Pain MedSep 1, 2026
Gabriela de Souza, Luiza Daux Buffon, Rafaela Hardt da Silva et al.
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In 30 seconds
This randomized controlled trial examined the effects of brainwave entrainment (BWE) versus music therapy on pain management in 84 women with fibromyalgia. The BWE group showed significant reductions in pain (P=0.0001) and anxiety (P=0.006), along with improvements in quality of life and depression compared to music therapy.
Key findings
- BWE significantly reduced pain as measured by VAS and MPQ (P=0.0001).
- Anxiety levels decreased in the BWE group (P=0.006).
- Quality of life improved more in the BWE group (P=0.002) compared to music therapy (P=0.035).
- Depression scores were significantly lower in the BWE group (P=0.0001) compared to music therapy (P=0.006).
Why it matters
The findings suggest that brainwave entrainment may offer a novel, non-pharmacological approach to managing fibromyalgia symptoms, potentially improving patient outcomes and quality of life.