Attenuating trauma- and cocaine-related intrusions by blocking memory reconsolidation with minocycline: protocol for a transdiagnostic randomized controlled trial.
Lina Dietiker, Amelie Zacher, Sofia de'Sperati et al.
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In 30 seconds
This randomized controlled trial investigates the effects of minocycline, an MMP-9 inhibitor, on intrusive memories in individuals with PTSD and cocaine use disorder. A total of 120 participants (60 with PTSD and 60 with cocaine use disorder) will receive either minocycline or placebo before reactivating their intrusive memories. The study aims to assess changes in memory-related mechanisms and neurobiological correlates.
Key findings
- Participants will receive a single dose of minocycline or placebo prior to memory reactivation.
- Intrusive memories will be assessed using ecological momentary assessment and pre-post questionnaires.
- Neurobiological correlates will be measured through fMRI, MRS, and peripheral biomarkers.
- The trial aims to inform future memory-focused interventions for trauma and addiction.
Why it matters
Understanding the mechanisms underlying intrusive memories in PTSD and substance use disorders can enhance treatment strategies. This study may provide insights into pharmacological interventions that target maladaptive memory processes, potentially improving outcomes for affected individuals.