Segmentectomy Versus Lobectomy in NSCLC With Pathologically Invasive Features: A Post Hoc Supplementary Analysis of Multicenter, Phase 3 Trial JCOG0802/WJOG4607L.
J Thorac OncolMay 11, 2026 (epub)
Shinya Katsumata, Atsushi Kamigaichi, Takaki Akamine et al.
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In 30 seconds
This post hoc analysis of the JCOG0802/WJOG4607L trial compared segmentectomy and lobectomy in 298 patients with clinical stage IA NSCLC exhibiting pathologically invasive features. Segmentectomy showed a trend toward improved overall survival (OS) with a hazard ratio of 0.657, although not statistically significant (p = 0.0936).
Key findings
- Segmentectomy showed a trend toward better overall survival compared to lobectomy (HR = 0.657).
- Cumulative incidence of death from other causes was significantly lower in the segmentectomy arm (HR = 0.359).
- Cumulative incidence of locoregional relapse was significantly higher in the segmentectomy group (HR = 2.234).
Why it matters
Understanding the comparative outcomes of segmentectomy versus lobectomy in NSCLC with invasive features is crucial for guiding surgical decisions and optimizing patient management strategies.