Oral manifestation and gingival biopsy contributing to the early diagnosis of Langerhans cell histiocytosis in a paediatric patient.
A A Kidwai, A Trimukhe, N Shrivastava et al.
✦ AI-curated · Sources linked
Case in brief
A 3-year-old child presented with bilateral osteolytic lesions, significant bone loss, and multiple ulcerative gingival lesions. Accompanying symptoms included lymphadenopathy and cranial pain. A family history of similar osteolytic lesions was noted. Histopathological analysis revealed S100-CD1a-positive histiocytes, confirming a diagnosis of Langerhans cell histiocytosis. Early biopsy facilitated timely multidisciplinary management.
Diagnostic / clinical pearl
Clinicians should consider Langerhans cell histiocytosis in pediatric patients presenting with osteolytic jaw lesions and gingival ulcerations, especially with a relevant family history.
Why it matters
This case highlights the importance of early biopsy in diagnosing complex conditions like LCH, which can significantly impact management and outcomes.