Risk factors for olfactory dysfunction after transsphenoidal pituitary adenoma resection: A systematic review and meta-analysis.
J Clin NeurosciMay 13, 2026 (epub)
Muyuan Jia, Gaoyuan Cui, Zhixiong Liu et al.
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In 30 seconds
This systematic review and meta-analysis evaluated risk factors for postoperative olfactory dysfunction in 802 adults undergoing transsphenoidal pituitary adenoma resection. Key findings indicated that advanced age, smoking history, and nasoseptal or nasal mucosal flap reconstruction increased the risk of olfactory dysfunction, while postoperative nasal irrigation may offer protection.
Key findings
- Advanced age was associated with increased risk of olfactory dysfunction.
- Smoking history significantly raised the likelihood of postoperative olfactory issues.
- Nasal mucosal flap reconstruction correlated with higher rates of olfactory dysfunction.
- Postoperative nasal irrigation showed a potential protective association.
Why it matters
Understanding the risk factors for olfactory dysfunction can help clinicians identify at-risk patients and potentially guide surgical techniques and postoperative care to mitigate this complication, which can significantly affect quality of life.