Reduced-Dose Total Skin Electron Beam Radiation Therapy in Mycosis Fungoides and Sézary Syndrome: Systematic Review and Meta-Analysis.
Int J Radiat Oncol Biol PhysMay 12, 2026 (epub)
Samir Abai, Moritz Fabian Danzer, Chalid Assaf et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the safety and efficacy of reduced-dose total skin electron beam therapy (TSEBT) in patients with mycosis fungoides and Sézary syndrome. Analyzing data from 22 studies involving 883 patients, the meta-analysis found a pooled overall response rate of 91% and a complete response rate of 26%.
Key findings
- The overall response rate to reduced-dose TSEBT was 91% (95% CI, 88-93).
- The complete response rate was 26% (95% CI, 21-31).
- All studies assessing quality of life reported significant improvements in one or more subdomains.
- 38% of patients received consolidation/subsequent therapy after TSEBT to maintain remission.
Why it matters
Understanding the efficacy of reduced-dose TSEBT is crucial for managing primary cutaneous T-cell lymphomas, as it offers a high response rate with minimal severe adverse effects, potentially improving patient quality of life.