Basaloid Squamous Cell Carcinoma of the Uterine Cervix: An Often Aggressive Subtype Frequently Underestimated by Cytology.
Yanqing Kong, Tao Cao, Qinjing Pan et al.
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Case in brief
A case of basaloid squamous cell carcinoma (BSCC) of the cervix was initially misdiagnosed as a high-grade squamous intraepithelial lesion (HSIL) based on liquid-based cytology. Upon histologic examination, the diagnosis of BSCC was confirmed, revealing distinctive cytologic features such as three-dimensional clusters and palisading. This case highlights the challenges in accurately diagnosing BSCC due to its cytological similarities with HSIL.
What made this case unusual
The cytologic presentation of BSCC can be deceptively bland, leading to misinterpretation as HSIL, which is atypical for this aggressive subtype.
Diagnostic / clinical pearl
Clinicians should be aware that basaloid squamous cell carcinoma may present with cytologic features that overlap with high-grade squamous intraepithelial lesions, necessitating careful evaluation.
Why it matters
Increased awareness of the distinctive cytologic patterns of BSCC is essential for accurate diagnosis and management, given its aggressive nature.