Relationships between rest-activity rhythms, cancer-related fatigue, and quality of life: Results from a time-restricted eating randomized controlled trial.
Chronobiol IntMay 14, 2026 (epub)
Amber S Kleckner, Yuanyuan Zhou, Yancy Diaz-Mercado et al.
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In 30 seconds
This randomized controlled trial investigated the relationship between rest-activity rhythms and cancer-related fatigue and quality of life in 31 adult cancer survivors over 12 weeks. Results indicated that stronger rest-activity rhythms correlated with lower fatigue and improved emotional well-being, with significant associations found for intradaily variability and the HMM-derived rhythm index (p = 0.040 and p = 0.037).
Key findings
- Stronger rest-activity rhythms were associated with lower fatigue and greater well-being.
- Intradaily variability was positively linked to emotional well-being (p = 0.040).
- Earlier daily activity peaks correlated with greater emotional well-being (p = 0.006).
- No significant effect of time-restricted eating on rest-activity parameters was observed.
Why it matters
Understanding the relationship between rest-activity rhythms and cancer-related symptoms can help identify potential biomarkers for fatigue and well-being, which may inform supportive care strategies for cancer survivors.