Ultrafiltration Rate in Prolonged Intermittent Kidney Replacement Therapy in Critically Ill Patients: A Randomized Controlled Trial.
Hemodial IntMay 14, 2026 (epub)
Clinical ResearchNephrology
Vijay Kalathia, Snehal Gaikwad, Vipul Chakurkar et al.
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In 30 seconds
This randomized controlled trial investigated the optimal ultrafiltration rate in critically ill patients with acute kidney injury undergoing prolonged intermittent kidney replacement therapy. The study found that a 4 mL/kg/h ultrafiltration rate resulted in a significantly lower incidence of hypotension compared to the 2 mL/kg/h and control groups, which were prescribed 2.65 mL/kg/h.
Key findings
- The 4 mL/kg/h ultrafiltration rate group had a significantly lower incidence of hypotension compared to the 2 mL/kg/h and control groups.
- Hypotension significantly increased the 30-day mortality risk in the study population.
- There was no significant difference in mean arterial pressure or vasopressor dependency index among the three groups.
Why it matters
Understanding the optimal ultrafiltration rate can help clinicians minimize complications such as hypotension in critically ill patients with acute kidney injury, potentially improving patient outcomes and reducing mortality risk.