Successful Cultivation of Oral Mucosal Epithelial Sheet Following Antifungal Therapy in Cases With Limbal Stem Cell Deficiency.
Koji Kitazawa, Hideki Fukuoka, Seitaro Komai et al.
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Case in brief
Four patients with limbal stem cell deficiency, two with Stevens-Johnson syndrome and two with ocular cicatricial pemphigoid, initially presented with Candida albicans contamination in oral mucosal biopsies intended for cultivated oral mucosal epithelial transplantation (COMET). Following targeted oral management and antifungal therapy, uncontaminated cultures were obtained, allowing successful generation and transplantation of epithelial sheets, leading to improved ocular surface stability.
Diagnostic / clinical pearl
Clinicians should prioritize preoperative dental assessments and antifungal treatments to prevent microbial contamination during the preparation of epithelial sheets for transplantation.