Clinicopathological Features and Outcomes of SMARCA4-Deficient Carcinomas of the Stomach and Gastroesophageal Junction: A Case Series and Literature Review.
Shao-Jie Sheng, Ting Lei, Xuan Wang et al.
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Case in brief
This report details five patients with SMARCA4-deficient gastric cancer, characterized by aggressive behavior and advanced stage at diagnosis. Surgical resection was performed in four patients, revealing ulcerated and transmural masses. Histological examination showed varied cellular arrangements, with one specimen containing a low-grade adenocarcinoma component. Postoperative chemotherapy was effective in two patients, while one patient with liver metastases was treated with immunotherapy and chemoradiation, surviving for 10 months.
Diagnostic / clinical pearl
Clinicians should consider SMARCA4 deficiency in the differential diagnosis of aggressive gastric tumors, as it may influence treatment decisions and prognosis.
Why it matters
Understanding the clinicopathological features of SMARCA4-deficient carcinomas can enhance diagnostic accuracy and inform management strategies for this aggressive cancer type.