Efficacy and Safety of Pancreatoscopy-Guided Laser Lithotripsy Versus Electrohydraulic Lithotripsy in Managing Pancreatic Duct Stone: A System Review and Meta-Analysis.
PancreasSep 12, 2026 (epub)
Clinical ResearchGastroenterology
Kaixuan Zhang, Zhongchen Fan, Haoyu Cheng et al.
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In 30 seconds
This meta-analysis compared the efficacy and safety of pancreatoscopy-guided laser lithotripsy (LL) and electrohydraulic lithotripsy (EHL) in treating refractory pancreatic duct stones in 326 patients. The study found no significant differences in technical success (78.9% for LL vs. 87.0% for EHL), clinical success (86.5% vs. 85.0%), or adverse event rates (8.8% vs. 10.0%).
Key findings
- Technical success rates were 78.9% for LL and 87.0% for EHL (P = 0.433).
- Clinical success rates were 86.5% for LL and 85.0% for EHL (P = 0.728).
- Adverse event rates were 8.8% for LL and 10.0% for EHL (P = 0.726).
- Substantial heterogeneity was observed for technical success.
Why it matters
Understanding the comparative efficacy and safety of LL and EHL is crucial for clinicians managing refractory pancreatic duct stones, as it informs treatment decisions based on available resources and operator expertise.