Multimodal intervention benefits: Responder analysis of J-MINT PRIME Kanagawa trial.
Arch Gerontol GeriatrMay 5, 2026 (epub)
Yuhei Chiba, Keiko Ide, Shoko Suzuki et al.
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In 30 seconds
The J-MINT PRIME Kanagawa trial, a randomized controlled trial, explored a multimodal intervention for dementia prevention in 188 older adults. Although the primary analysis showed no significant benefits, a responder analysis identified a 'Target Group' of 108 participants who had an MMSE score < 28. In this group, the intervention significantly preserved MMSE trajectories compared to controls (P = 0.022).
Key findings
- The 'Target Group' had an MMSE score < 28 or specific metabolic ranges.
- In the Target Group, the intervention preserved MMSE trajectories compared to controls (P = 0.022).
- The Non-Target Group, with MMSE ≥ 28, showed no significant interaction over time.
Why it matters
Identifying responsive subpopulations for dementia prevention interventions can enhance the effectiveness of treatment strategies. This study highlights the importance of targeting specific groups to potentially improve cognitive outcomes.