Primary Small Cell Neuroendocrine Carcinoma of the Gallbladder With Liver Metastases: Case Report and Narrative Review.
Xufan Yi, Feifei Song, Wenjie Hu et al.
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Case in brief
An 80-year-old woman presented with a 10-day history of intermittent epigastric pain radiating to the back. Imaging studies, including abdominal ultrasound and contrast-enhanced CT, revealed a mass at the gallbladder fundus invading adjacent liver segments, along with multiple hepatic lesions. A biopsy confirmed the diagnosis of primary small cell neuroendocrine carcinoma (SCNEC).
Diagnostic / clinical pearl
Primary small cell neuroendocrine carcinoma of the gallbladder is rare and often presents at an advanced stage, making early diagnosis challenging. Multimodal imaging and timely histopathologic confirmation are essential.
Why it matters
Recognizing the aggressive nature of gallbladder SCNEC is crucial for timely intervention, as it typically has a poor prognosis and requires a multidisciplinary approach for optimal management.