Associations Between Multimorbidity, Polypharmacy and Oral Conditions in Older Adults: A Systematic Review and Meta-Analysis.
GerodontologyMay 17, 2026 (epub)
Kittipit Srisanoi, Sabrina Maniewicz, Claudio Rodrigues Leles et al.
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In 30 seconds
This systematic review and meta-analysis examined the relationship between multimorbidity, polypharmacy, and oral health in older adults aged 75 and older. The analysis included 23 studies and found that polypharmacy was significantly associated with dry mouth (OR = 2.05; 95% CI: 1.31-3.22), while associations with multimorbidity were inconsistent.
Key findings
- Polypharmacy was significantly associated with dry mouth (OR = 2.05; 95% CI: 1.31-3.22).
- Higher medication counts correlated with increased instances of dry mouth and hyposalivation.
- Poor oral health assessment tool (OHAT) scores were consistently linked to polypharmacy.
- Multimorbidity showed inconsistent associations with oral health outcomes.
Why it matters
Understanding the impact of polypharmacy on oral health is crucial for managing older adults, as it may lead to complications such as dry mouth, which can affect overall health and quality of life.