68 Ga-PSMA Scintigraphy of Cervicothoracic Ganglioneuroma.
Zeinab Amirkhani, Amin Saber Tanha, Ramin Sadeghi et al.
✦ AI-curated · Sources linked
Case in brief
A 67-year-old man with newly diagnosed prostate adenocarcinoma underwent 68 Ga-PSMA PET/CT for staging, revealing a solitary PSMA-avid lesion at the thoracic inlet. Despite its location suggesting a non-cancerous origin, the intense radiotracer uptake raised concerns for metastasis. Histopathological analysis ultimately identified the lesion as a ganglioneuroma, highlighting the diagnostic challenge.
What made this case unusual
The ganglioneuroma exhibited high PSMA avidity, which is atypical and can lead to misinterpretation as metastatic disease.
Diagnostic / clinical pearl
Clinicians should be aware that ganglioneuromas can show significant PSMA uptake, potentially mimicking metastatic prostate cancer on imaging.
Why it matters
Recognizing this possibility is crucial to avoid misdiagnosis and ensure appropriate management for patients with PSMA-targeted imaging findings.